Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes.

ABSTRACT: A phthaloyl-protected aminooxymethyl-C-2'-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.

SUBMITTER: Maity SK 

PROVIDER: S-EPMC6854833 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature