Clinical evidence of abscopal effect in cutaneous squamous cell carcinoma treated with diffusing alpha emitters radiation therapy: a case report.

ABSTRACT:

Purpose

Alpha particle treatments could enhance the probability of an immune response, which can lead to abscopal effects (AE). We report a case of a patient affected by multiple cutaneous squamous cell carcinoma (cSCC). After the treatment with diffusing alpha emitters radiation therapy (DaRT) of one lesion, an AE was observed on at least two distant ones.

Material and methods

We investigated a case of a 65-year-old female patient with multiple synchronous lesions of the skin of lower limbs confirmed by a biopsy. Patient was enrolled in a clinical trial N.CTP-SCC-00 (NCT03015883), with the objective to assess effectiveness of DaRT technique. DaRT is based on the insertion of locally ²²⁴Ra-loaded seeds in a clinical target volume (CTV). Treatment plan with positro

SUBMITTER: Bellia SR 

PROVIDER: S-EPMC6854861 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature