Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses.

ABSTRACT:

Background

Ca²⁺ release-activated Ca²⁺ channels (CRAC) are the main Ca²⁺ entry pathway regulating intracellular Ca²⁺ concentration in a variety of cancer types. Orai2 is the main pore-forming subunit of CRAC channels in central neurons. To explore the role of Orai2 in glioblastoma (GBM), we investigated the key pathways and genes in Orai2-mediated GBM by bioinformatic analyses.

Methods

Via The Cancer Genome Atlas (TCGA), French, Sun, and Gene Expression Omnibus (GEO) (GDS3885) datasets, we collected 1231 cases with RNA-seq data and analyzed the functional annotation of Orai2 by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Univariate and multivariate survival analyses were applied to 823 pa

SUBMITTER: Yuan F 

PROVIDER: S-EPMC6855003 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature