Mutant Prevention Concentration of Ciprofloxacin against Klebsiella pneumoniae Clinical Isolates: An Ideal Prognosticator in Treating Multidrug-Resistant Strains.

ABSTRACT:

Background

Fluoroquinolone-resistant Klebsiella pneumoniae poses a therapeutic challenge when implicated in urinary tract infections, pyelonephritis, pneumonia, skin infections, osteomyelitis, and respiratory infections. The mutant prevention concentration (MPC) represents a concentration threshold above which increase of resistant mutants occurs rarely. The aim of the present study is to determine the MPC among ciprofloxacin-resistant K. pneumoniae clinical isolates.

Materials and methods

A total of 240 clinical isolates of K. pneumoniae were collected from a tertiary care hospital. The MPCs were determined for 24 selected strains using an inoculum of 10¹⁰ CFU/ml in Müller-Hinton agar plates with serial/various concentrations (0.003-100 μ<

SUBMITTER: Aditi Priyadarshini B 

PROVIDER: S-EPMC6855012 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature