Identified the Synergistic Mechanism of Drynariae Rhizoma for Treating Fracture Based on Network Pharmacology.

ABSTRACT:

Background

Drynariae Rhizoma (DR) has been widely used in the prevention and treatment of various fractures. However, the specific mechanisms of DR's active ingredients have not been elucidated. The purpose of this study was to explore the synergistic mechanisms of DR for treating fracture.

Methods

A network pharmacology approach integrating ingredient screening, target exploration, active ingredients-gene target network construction, protein-protein interaction network construction, molecular docking, gene-protein classification, gene ontology (GO) functional analysis, KEGG pathway enrichment analysis, and signaling pathway integration was used.

Results

This approach identified 17 active ingredients of DR, interacting with 144 common gene targets and 143 prote

SUBMITTER: Lin H 

PROVIDER: S-EPMC6855049 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature