MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold.

ABSTRACT:

Context

In rodents, cold exposure induces the activation of brown adipose tissue (BAT) and the induction of intracellular triacylglycerol (TAG) lipolysis. However, in humans, the kinetics of supraclavicular (SCV) BAT activation and the potential importance of TAG stores remain poorly defined.

Objective

To determine the time course of BAT activation and changes in intracellular TAG using MRI assessment of the SCV (i.e., BAT depot) and fat in the posterior neck region (i.e., non-BAT).

Design

Cross-sectional.

Setting

Clinical research center.

Patients or other participants

Twelve healthy male volunteers aged 18 to 29 years [body mass index = 24.7 ± 2.8 kg/m² and body fat percentage = 25.0% ± 7.4% (both, mean ± SD)].

Interventions

SUBMITTER: Oreskovich SM 

PROVIDER: S-EPMC6855213 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature