CD3⁺ Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site.

ABSTRACT: Macrophages are essential cells of the innate immune response against microbial infections, and they have the ability to adapt under both pro- and anti-inflammatory conditions and develop different functions. A growing body of evidence regarding a novel macrophage subpopulation that expresses CD3 has recently emerged. Here, we explain that human circulating monocytes can be differentiated into CD3⁺TCRαβ⁺ and CD3⁺TCRαβ^- macrophages. Both cell subpopulations express on their cell surface HLA family molecules, but only the CD3⁺TCRαβ⁺ macrophage subpopulation co-express CD1 family molecules and transmembrane TNF (tmTNF). CD3⁺TCRαβ⁺ macrophages secrete IL-1β, IL-6 IP-10, and MCP-1 by both tmTNF- and CD3-depe

SUBMITTER: Rodriguez-Cruz A 

PROVIDER: S-EPMC6855269 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature