A Panel of Circulating MicroRNAs Detects Uveal Melanoma With High Precision.

ABSTRACT:

Purpose

To determine if a circulating microRNA (miRNA) panel could be used to distinguish between uveal melanoma and uveal nevi.

Methods

We report on a multicenter, cross-sectional study conducted between June 2012 and September 2015. The follow-up time was approximately 3 to 5 years. Blood was drawn from participants presenting with a uveal nevus (n = 10), localized uveal melanoma (n = 50), or metastatic uveal melanoma (n = 5). Levels of 17 miRNAs were measured in blood samples of study participants using a sensitive real-time PCR system.

Results

A panel of six miRNAs (miR-16, miR-145, miR-146a, miR-204, miR-211, and miR-363-3p) showed significant differences between participants with uveal nevi compared with patients with localized and metastati

SUBMITTER: Stark MS 

PROVIDER: S-EPMC6855372 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature