Dendritic Spikes Expand the Range of Well Tolerated Population Noise Structures.

ABSTRACT: The brain operates surprisingly well despite the noisy nature of individual neurons. The central mechanism for noise mitigation in the nervous system is thought to involve averaging over multiple noise-corrupted inputs. Subsequently, there has been considerable interest in identifying noise structures that can be integrated linearly in a way that preserves reliable signal encoding. By analyzing realistic synaptic integration in biophysically accurate neuronal models, I report a complementary denoising approach that is mediated by focal dendritic spikes. Dendritic spikes might seem to be unlikely candidates for noise reduction due to their miniscule integration compartments and poor averaging abilities. Nonetheless, the extra thresholding step introduced by dendritic spike generation increa

SUBMITTER: Poleg-Polsky A 

PROVIDER: S-EPMC6855677 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature