Stimulating the hippocampal posterior-medial network enhances task-dependent connectivity and memory.

ABSTRACT: Successful episodic memory involves dynamic increases in activity across distributed hippocampal networks, including the posterior-medial (PMN) and the anterior-temporal (ATN) networks. We tested whether this up-regulation of functional connectivity during memory processing can be enhanced within hippocampal networks by noninvasive stimulation, and whether such task-dependent connectivity enhancement predicts memory improvement. Participants received stimulation targeting the PMN or an out-of-network control location. We compared the effects of stimulation on fMRI connectivity during an autobiographical retrieval task versus during rest within the PMN and the ATN. PMN-targeted stimulation significantly increased connectivity during autobiographical retrieval versus rest within the PMN. Thi

SUBMITTER: Warren KN 

PROVIDER: S-EPMC6855798 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature