Differences in Genomic Profiles and Outcomes Between Thoracic and Adrenal Neuroblastoma.

ABSTRACT:

Background

Neuroblastoma is a biologically and clinically heterogeneous disease. Based on recent studies demonstrating an association between the primary tumor site, prognosis, and commonly measured tumor biological features, we hypothesized that neuroblastomas arising in different sites would show distinct genomic features reflective of the developmental biology of the sympathicoadrenal nervous system.

Methods

We first compared genomic and epigenomic data of primary diagnostic neuroblastomas originating in the adrenal gland (n = 646) compared to thoracic sympathetic ganglia (n = 118). We also evaluated association of common germline variation with these primary sites in 1027 European-American neuroblastoma patients.

Results

We observed higher rates of MYCN amplificat

SUBMITTER: Oldridge DA 

PROVIDER: S-EPMC6855946 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature