Treatment Outcomes and Dose Rate Effects Following Gamma Knife Stereotactic Radiosurgery for Vestibular Schwannomas.

ABSTRACT:

Background

Gamma Knife radiosurgery (GKRS; Elekta AB) remains a well-established treatment modality for vestibular schwannomas. Despite highly effective tumor control, further research is needed toward optimizing long-term functional outcomes. Whereas dose-rate effects may impact post-treatment toxicities given tissue dose-response relationships, potential effects remain largely unexplored.

Objective

To evaluate treatment outcomes and potential dose-rate effects following definitive GKRS for vestibular schwannomas.

Methods

We retrospectively reviewed 419 patients treated at our institution between 1998 and 2015, characterizing baseline demographics, pretreatment symptoms, and GKRS parameters. The cohort was divided into 2 dose-rate groups based on the median value (2.

SUBMITTER: Smith DR 

PROVIDER: S-EPMC6855984 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature