Ecotropic viral integration site 1 regulates EGFR transcription in glioblastoma cells.

ABSTRACT:

Purpose

Ecotropic viral integration site-1 (EVI1) is a transcription factor that contributes to the unfavorable prognosis of leukemia, some epithelial cancers, and glial tumors. However, the biological function of EVI1 in glioblastoma multiforme (GBM) remains unclear. Based on microarray experiments, EVI1 has been reported to regulate epidermal growth factor receptor (EGFR) transcription. Signal transduction via EGFR plays an essential role in glioblastoma. Therefore, we performed this study to clarify the importance of EVI1 in GBM by focusing on the regulatory mechanism between EVI1 and EGFR transcription.

Methods

We performed immunohistochemical staining and analyzed the EVI1-expression in glioma tissue. To determine the relationship between EVI1 and EGFR, we induced siRNA

SUBMITTER: Mizuguchi A 

PROVIDER: S-EPMC6856030 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature