Optimal Sampling Strategies for Therapeutic Drug Monitoring of First-Line Tuberculosis Drugs in Patients with Tuberculosis.

ABSTRACT:

Background

The 24-h area under the concentration-time curve (AUC₂₄)/minimal inhibitory concentration ratio is the best predictive pharmacokinetic/pharmacodynamic (PK/PD) parameter of the efficacy of first-line anti-tuberculosis (TB) drugs. An optimal sampling strategy (OSS) is useful for accurately estimating AUC₂₄; however, OSS has not been developed in the fed state or in the early phase of treatment for first-line anti-TB drugs.

Methods

An OSS for the prediction of AUC₂₄ of isoniazid, rifampicin, ethambutol and pyrazinamide was developed for TB patients starting treatment. A prospective, randomized, crossover trial was performed during the first 3 days of treatment in which first-line anti-TB drugs were administered either intravenously or

SUBMITTER: Saktiawati AMI 

PROVIDER: S-EPMC6856034 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature