Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared.

ABSTRACT: Vitamin C (VC) and vitamin D (VD) have been widely used as the dietary supplements and in treatment of diseases both independently and in combination. Whether there is a connection between their pathways is critical for their therapeutic applications. Using whole-genome expression profiles, we performed multiple measures of associations, networks, eQTL mappings and expressions of key genes of interest in VC and VD functions. Several key genes in their pathways were found to be associated. Gc and Rgn play important roles connecting VC and VD pathways in mice. The r values of expression levels between Gc and Rgn in mouse spleen, liver, lung, and kidney are 0.937, 0.558, 0.901, and 0.617, respectively. The expression QTLs of Gc and Rgn are mapped onto the same locations, i.e., 68-76 MB in chr

SUBMITTER: Dong W 

PROVIDER: S-EPMC6856197 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature