Thearubigin regulates the production of Nrf2 and alleviates LPS-induced acute lung injury in neonatal rats.

ABSTRACT: This study was undertaken to investigate the effect of natural bioactive compound thearubigin on neonatal acute lung injury (ALI) using LPS-induced ALI as a model. We also attempted to understand the possible underlying mechanism. The effect of thearubigin on lung wet-to-dry weight ratio, the activity of LDH, lung histopathology, BALF protein levels, the activity of MPO, production and extravasation of cytokines and oxidative stress were studied. The results showed that thearubigin caused a significant reduction in lung inflammation as evident from lung wet-to-dry weight ratio, BALF protein levels and MPO activity and histopathological analysis. It was further observed that the attenuation in inflammation happened due to a significant reduction in cytokine levels in alveolar cavities. Thea

SUBMITTER: Wang X 

PROVIDER: S-EPMC6856253 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature