Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies.

ABSTRACT: Parvalbumin interneurons are fast-spiking GABAergic neurons that provide inhibitory control of cortical and subcortical circuits and are thought to be a key locus of the pathophysiology underlying schizophrenia. In view of the contradictory results regarding the nature of parvalbumin post-mortem findings in schizophrenia, we conducted a quantitative meta-analysis of the data on parvalbumin cell density and parvalbumin mRNA levels in pre-frontal regions in the brains of patients with schizophrenia (n = 274) compared with healthy controls (n = 275). The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges' g = - 0.27; p = 0.03) and there is a non-significant reduction in parvalbumin mRNA levels (g = - 0.44; p = 0.12

SUBMITTER: Kaar SJ 

PROVIDER: S-EPMC6856257 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature