Glucose-Mediated Repression of Plant Biomass Utilization in the White-Rot Fungus Dichomitus squalens.

ABSTRACT: The extent of carbon catabolite repression (CCR) at a global level is unknown in wood-rotting fungi, which are critical to the carbon cycle and are a source of biotechnological enzymes. CCR occurs in the presence of sufficient concentrations of easily metabolizable carbon sources (e.g., glucose) and involves downregulation of the expression of genes encoding enzymes involved in the breakdown of complex carbon sources. We investigated this phenomenon in the white-rot fungus Dichomitus squalens using transcriptomics and exoproteomics. In D. squalens cultures, approximately 7% of genes were repressed in the presence of glucose compared to Avicel or xylan alone. The glucose-repressed genes included the essential components for utilization of plant biomass-carbohydrate-a

SUBMITTER: Daly P 

PROVIDER: S-EPMC6856337 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature