2CS-CHX^T Operon Signature of Chlorhexidine Tolerance among Enterococcus faecium Isolates.

ABSTRACT: Chlorhexidine (CHX) is a broad-spectrum antiseptic widely used in community and clinical contexts for many years that has recently acquired higher relevance in nosocomial infection control worldwide. Despite this, CHX tolerance among Enterococcus faecium bacteria, representing one of the leading agents causing nosocomial infections, has been poorly understood. This study provides new phenotypic and molecular data for better identification of CHX-tolerant E. faecium subpopulations in community and clinical contexts. The chlorhexidine MIC (MIC_CHX) distribution of 106 E. faecium isolates suggested the occurrence of tolerant subpopulations in diverse sources (human, animal, food, environment) and phylogenomic backgrounds (clades A1/A2/B), with predominance in cl

SUBMITTER: Duarte B 

PROVIDER: S-EPMC6856339 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature