High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence.

ABSTRACT: Acute myocardial ischemia is a precursor of sudden arrhythmic death. Variability in its manifestation hampers understanding of arrhythmia mechanisms and challenges risk stratification. Our aim is to unravel the mechanisms underlying how size, transmural extent and location of ischemia determine arrhythmia vulnerability and ECG alterations. High performance computing simulations using a human torso/biventricular biophysically-detailed model were conducted to quantify the impact of varying ischemic region properties, including location (LAD/LCX occlusion), transmural/subendocardial ischemia, size, and normal/slow myocardial propagation. ECG biomarkers and vulnerability window for reentry were computed in over 400 simulations for 18 cases evaluated. Two distinct mechanisms explained larger vu

SUBMITTER: Martinez-Navarro H 

PROVIDER: S-EPMC6856379 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature