A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication.

ABSTRACT:

Background

Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore application of minimally invasive drug sampling techniques, such as dried blood spots (DBS), may enhance the enrollment of children in PK studies. The objectives of this study were to compare solithromycin concentrations in DBS with those in liquid plasma samples (LPS) and to quantify the effects of modeling DBS concentrations on the results of a population PK model.

Methods

Comparability analysis was performed on matched DBS and LPS solithromycin concentrations collected from two different phase 1 clinical trials of solithromycin treatment i

SUBMITTER: Beechinor RJ 

PROVIDER: S-EPMC6856424 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature