Gut Vibes in Parkinson's Disease: The Microbiota-Gut-Brain Axis.

ABSTRACT:

Background

The complexity of the pathogenic mechanisms underlying neurodegenerative disorders such as Parkinson's disease (PD) is attributable to multifactorial changes occurring at a molecular level, influenced by genetics and environmental interactions. However, what causes the main hallmarks of PD is not well understood. Recent data increasingly suggest that imbalances in the gut microbiome composition might trigger and/or exacerbate the progression of PD.

Objective

The present review aims to (1) report emerging literature showing changes in microbiota composition of PD patients compared to healthy individuals and (2) discuss how these changes may initiate and/or perpetuate PD pathology.

Methods

We analyzed 13 studies published from 2015 and included in this review

SUBMITTER: Bullich C 

PROVIDER: S-EPMC6856467 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature