Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis.

ABSTRACT:

Objective

Intrathecal inflammation, compartmentalized in cerebrospinal fluid (CSF) and in meningeal infiltrates, has fundamental role in inflammation, demyelination, and neuronal injury in cerebral cortex in multiple sclerosis (MS). Since the exact link between intrathecal inflammation and mechanisms of cortical pathology remains unknown, we aimed to investigate a detailed proteomic CSF profiling which is able to reflect cortical damage in early MS.

Methods

We combined new proteomic method, TRIDENT, CSF analysis, and advanced 3T magnetic resonance imaging (MRI), in 64 MS patients at the time of diagnosis and 26 controls with other neurological disorders. MS patients were stratified according to cortical lesion (CL) load.

Results

We identified 227 proteins differently

SUBMITTER: Magliozzi R 

PROVIDER: S-EPMC6856609 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature