Influence of Prediabetes on the Effects of Intensive Systolic Blood Pressure Control on Kidney Events.

ABSTRACT: BACKGROUND:More than one-third of US adults have prediabetes, which is typically accompanied by hypertension. METHODS:We examined whether prediabetes modified the effects of intensive systolic blood pressure (SBP) lowering on the incidence of chronic kidney disease (CKD) and acute kidney injury (AKI) events in a post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). Diabetes was a SPRINT exclusion criterion. We defined normoglycemia and prediabetes as fasting plasma glucose <100 mg/dl and ≥100 mg/dl, respectively. RESULTS:Of the 9,323 participants included in this analysis, 3,898 (41.8%) had prediabetes and the rest (5,425) had normoglycemia. In participants with baseline estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2, incident CKD was defined as a ≥3

SUBMITTER: Rathi N 

PROVIDER: S-EPMC6856623 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature