Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter.

ABSTRACT:

Objective

Astrocytes have gained attention as important players in neurological disease. In line with their heterogeneous character, defects in specific astrocyte subtypes have been identified. Leukodystrophy vanishing white matter (VWM) shows selective vulnerability in white matter astrocytes, but the underlying mechanisms remain unclear. Induced pluripotent stem cell technology is being extensively explored in studies of pathophysiology and regenerative medicine. However, models for distinct astrocyte subtypes for VWM are lacking, thereby hampering identification of disease-specific pathways.

Methods

Here, we characterize human and mouse pluripotent stem cell-derived gray and white matter astrocyte subtypes to generate an in vitro VWM model. We examined morphology and func

SUBMITTER: Leferink PS 

PROVIDER: S-EPMC6856690 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature