Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential.

ABSTRACT: The gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the relationships between the gut microbiota and several gut alterations, including colorectal cancer. Changes in the gut microbiota in patients suffering colorectal cancer suggest a possible role of host-microbe interactions in the origin and development of this malignancy and, at the same time, open the door for novel ways of preventing, diagnosing, or treating this disease. In this review we survey current knowledge on the healthy microbiome of the gut and how it is altered in colorectal cancer and other related disease conditions. In describing past studies we will critically assess technical limitations of different approaches and point to

SUBMITTER: Saus E 

PROVIDER: S-EPMC6856719 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature