Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells.

ABSTRACT: Regulatory B cells (Bregs) play a critical role in the control of autoimmunity and inflammation. IL-10 production is the hallmark for the identification of Bregs. However, the molecular determinants that regulate the transcription of IL-10 and control the Breg developmental program remain unknown. Here, we demonstrate that aryl hydrocarbon receptor (AhR) regulates the differentiation and function of IL-10-producing CD19⁺CD21^hiCD24^hiBregs and limits their differentiation into B cells that contribute to inflammation. Chromatin profiling and transcriptome analyses show that loss of AhR in B cells reduces expression of IL-10 by skewing the differentiation of CD19⁺CD21^hiCD24^hiB cells into a pro-inflammatory program, under Breg-in

SUBMITTER: Piper CJM 

PROVIDER: S-EPMC6856759 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature