Multiple Oscillatory Push-Pull Antagonisms Constrain Seizure Propagation.

ABSTRACT:

Objective

Drug-resistant focal epilepsy is widely recognized as a network disease in which epileptic seizure propagation is likely coordinated by different neuronal oscillations such as low-frequency activity (LFA), high-frequency activity (HFA), or low-to-high cross-frequency coupling. However, the mechanism by which different oscillatory networks constrain the propagation of focal seizures remains unclear.

Methods

We studied focal epilepsy patients with invasive electrocorticography (ECoG) recordings and compared multilayer directional network interactions between focal seizures either with or without secondary generalization. Within-frequency and cross-frequency directional connectivity were estimated by an adaptive directed transfer function and cross-frequency direction

SUBMITTER: Jiang H 

PROVIDER: S-EPMC6856814 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature