Integrated Analys of High-Fat Challenge-Induced Changes in Blood Cell Whole-Genome Gene Expression.

ABSTRACT:

Scope

Several studies have examined the whole-genome gene expression response in blood cells to high-fat challenges with differing results. The study aims to identify consistently up- or downregulated genes and pathways in response to a high-fat challenge using several integration methods.

Methods and results

Three studies measuring the gene expression response to a high-fat challenge in white blood cells are evaluated for common trends using several integration methods. Overlap in differentially expressed genes between separate studies is examined, p-values of each separate study are combined, and data are analyzed as one merged dataset. Differentially expressed genes and pathways are compared between these methods. Selecting genes differentially expressed in the three sepa

SUBMITTER: Matualatupauw JC 

PROVIDER: S-EPMC6856827 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature