Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases.

ABSTRACT: Epigenetic mechanisms, especially DNA methylation and histone modifications, are dynamic processes that regulate the gene expression transcriptional program in normal and diseased states. The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that, via bromodomains, regulate gene transcription by binding to acetylated lysine residues on histones and master transcriptional factors. Experimental data have demonstrated the involvement of some BET proteins in many pathological conditions, including tumor development, infections, autoimmunity, and inflammation. Selective bromodomain inhibitors are epigenetic drugs that block the interaction between BET proteins and acetylated proteins, thus exerting beneficial effects. Recent data have describ

SUBMITTER: Morgado-Pascual JL 

PROVIDER: S-EPMC6857099 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature