Association of endemic goitre and exceptional longevity in Sardinia: evidence from an ecological study.

ABSTRACT: This study aims to test the hypothesis that a high prevalence of endemic goitre, considered as a proxy measure for subclinically reduced thyroid function in the population, is geographically associated with exceptional longevity. Using historical data available for 377 Sardinian municipalities in the first half of the twentieth century, we performed an ecological study to investigate the geographic distribution of goitre and its spatial association with demographic indicators of population longevity. This analysis was conducted by using both conventional ordinary least square and geographically weighted regression models to take into account spatial autocorrelation and included other longevity-associated factors previously identified in Sardinia. The spatial analysis revealed that the goit

SUBMITTER: Tolu F 

PROVIDER: S-EPMC6857103 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature