Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.

ABSTRACT:

Background

Different oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinson's disease (PD) across early stage to middle stage by using graph theory-based analysis.

Methods

Eighty-eight PD patients including 39 PD patients in the early stage (EPD) and 49 patients in the middle stage (MPD) and 36 controls were recruited in the present study. Graph theory-based network analyses from three oscillation frequencies (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.198 Hz) were analyzed. Nodal metrics (e.g. nodal degree centrality, betweenness centrality and nodal efficiency) were calculated.

Results

Our results showed that (1) a divergent ef

SUBMITTER: Guan X 

PROVIDER: S-EPMC6857322 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature