Recapitulation-like developmental transitions of chromatin accessibility in vertebrates.

ABSTRACT: The relationship between development and evolution has been a central theme in evolutionary developmental biology. Across the vertebrates, the most highly conserved gene expression profiles are found at mid-embryonic, organogenesis stages, whereas those at earlier and later stages are more diverged. This hourglass-like pattern of divergence does not necessarily rule out the possibility that gene expression profiles that are more evolutionarily derived appear at later stages of development; however, no molecular-level evidence of such a phenomenon has been reported. To address this issue, we compared putative gene regulatory elements among different species within a phylum. We made a genome-wide assessment of accessible chromatin regions throughout embryogenesis in three vertebrate species

SUBMITTER: Uesaka M 

PROVIDER: S-EPMC6857340 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature