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Patient characteristics, burden and pharmacotherapy of treatment-resistant schizophrenia: results from a survey of 204 US psychiatrists.


ABSTRACT: BACKGROUND:Minimal/non-response to antipsychotic treatment, and persistent positive symptoms despite treatment, are common among patients with schizophrenia. The aim of this study was to characterize a US treatment-resistant schizophrenia (TRS) population in terms of patient demographics, burden of symptoms, treatment history, and factors influencing therapeutic choice. METHODS:In an online survey, 204 psychiatrists self-selected and completed three patient records: two TRS and one schizophrenia ('non-TRS'). RESULTS:Respondents reported that 29.5% of their schizophrenia caseload had TRS. Selected TRS (n?=?408) vs non-TRS (n?=?204) patients were more likely to be unemployed (74.5% vs 45.1%, p?

SUBMITTER: Correll CU 

PROVIDER: S-EPMC6857350 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Patient characteristics, burden and pharmacotherapy of treatment-resistant schizophrenia: results from a survey of 204 US psychiatrists.

Correll Christoph U CU   Brevig Thomas T   Brain Cecilia C  

BMC psychiatry 20191114 1


<h4>Background</h4>Minimal/non-response to antipsychotic treatment, and persistent positive symptoms despite treatment, are common among patients with schizophrenia. The aim of this study was to characterize a US treatment-resistant schizophrenia (TRS) population in terms of patient demographics, burden of symptoms, treatment history, and factors influencing therapeutic choice.<h4>Methods</h4>In an online survey, 204 psychiatrists self-selected and completed three patient records: two TRS and on  ...[more]

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