Lipocalin 2 Protects Against Escherichia coli Infection by Modulating Neutrophil and Macrophage Function.

ABSTRACT: Lipocalin 2 (Lcn2) is an essential component of the antimicrobial innate immune system. It attenuates bacterial growth by binding and sequestering the iron-scavenging siderophores to prevent bacterial iron acquisition. Whereas, the ability of Lcn2 to sequester iron is well-described, the role of Lcn2 in regulating immune cells during bacterial infection remains unclear. In this study, we showed that upon infection with Escherichia coli (O157:H7), Lcn2-deficient (Lcn2^-/-) mice carried more bacteria in blood and liver, and the acute-phase sera lost their antibacterial activity in vitro. Neutrophils from Lcn2^-/- mice were defective in homeostasis and morphological development. E. coli O157:H7 infection of Lcn2^-/- mice

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6857527 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature