Rhodium-Catalyzed Hydrofunctionalization: Enantioselective Coupling of Indolines and 1,3-Dienes.

ABSTRACT: We communicate a strategy for the hydrofunctionalization of 1,3-dienes via Rh-hydride catalysis. Conjugated dienes are coupled to nucleophiles to demonstrate the feasibility of novel C-C, C-O, C-S, and C-N bond forming processes. In the presence of a chiral JoSPOphos ligand, hydroamination generates chiral allylic amines with high regio- and enantioselectivity. Tuning both the pK_a and steric properties of an acid-additive is critical for enantiocontrol.

SUBMITTER: Yang XH 

PROVIDER: S-EPMC6857534 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature