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Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp⁶²⁰ Risk Allele Drive the Expansion of FOXP3⁺ Regulatory T Cells and PD-1 Expression.

ABSTRACT: In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4⁺ T-cell activity. However, to date, the characterization of the CD4⁺ regulatory T cell (Treg) compartment in SLE has yielded conflicting results. Here we show that patients have an increased frequency of CD4⁺FOXP3⁺ cells in circulation owing to a specific expansion of thymically-derived FOXP3⁺HELIOS⁺ Tregs with a demethylated FOXP3 Treg-specific demethylated region. We found that the Treg expansion was strongly associated with markers of recent immune activation, including PD-1, plasma concentrations of IL-2 and the type I interferon biomarker soluble SIGLEC-1. Since the expression of

SUBMITTER: Ferreira RC

PROVIDER: S-EPMC6857542 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Dataset Information

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp⁶²⁰ Risk Allele Drive the Expansion of FOXP3⁺ Regulatory T Cells and PD-1 Expression.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp⁶²⁰ Risk Allele Drive the Expansion of FOXP3⁺ Regulatory T Cells and PD-1 Expression.