Reversible solidification of fission yeast cytoplasm after prolonged nutrient starvation.

ABSTRACT: Cells depend on a highly ordered organisation of their content and must develop strategies to maintain the anisotropic distribution of organelles during periods of nutrient shortage. One of these strategies is to solidify the cytoplasm, which was observed in bacteria and yeast cells with acutely interrupted energy production. Here, we describe a different type of cytoplasm solidification fission yeast cells switch to, after having run out of nutrients during multiple days in culture. It provides the most profound reversible cytoplasmic solidification of yeast cells described to date. Our data exclude the previously proposed mechanisms for cytoplasm solidification in yeasts and suggest a mechanism that immobilises cellular components in a size-dependent manner. We provide experimental evide

SUBMITTER: Heimlicher MB 

PROVIDER: S-EPMC6857596 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature