Macrocycles of higher ortho-phenylenes: assembly and folding.

ABSTRACT: Higher-order structure in abiotic foldamer systems represents an important but largely unrealized goal. As one approach to this challenge, covalent assembly can be used to assemble macrocycles with foldamer subunits in well-defined spatial relationships. Such systems have previously been shown to exhibit self-sorting, new folding motifs, and dynamic stereoisomerism, yet there remain important questions about the interplay between folding and macrocyclization and the effect of structural confinement on folding behavior. Here, we explore the dynamic covalent assembly of extended ortho-phenylenes (hexamer and decamer) with rod-shaped linkers. Characteristic ¹H chemical shift differences between cyclic and acyclic systems can be compared with computational conformer libraries

SUBMITTER: Kinney ZJ 

PROVIDER: S-EPMC6857672 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature