Brief Report: Adipogenic Expression of Brown Fat Genes in HIV and HIV-Related Parameters.

ABSTRACT:

Context

Persons with HIV are at increased risk for adipose dysfunction, which could mediate metabolic complications such as cardiovascular disease, fatty liver disease, and diabetes. We have previously reported reduced browning and beiging capacity of the subcutaneous adipose depot in HIV.

Objective

We sought to evaluate how HIV-related parameters are related to the expression of brown and beige fat genes in the abdominal subcutaneous adipose tissue.

Design

Eighteen persons with HIV underwent punch biopsy of abdominal subcutaneous fat to determine mRNA expression of adipose-related genes using quantitative reverse transcriptase-polymerase chain reaction.

Results

Duration of antiretroviral therapy use, particularly related to protease inhibitor use, was signific

SUBMITTER: Srinivasa S 

PROVIDER: S-EPMC6857717 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature