Estimation of fibrosis progression rates for chronic hepatitis C: a systematic review and meta-analysis update.

ABSTRACT:

Objectives

Mathematical models are increasingly important in planning for the upcoming chronic hepatitis C (CHC) elimination efforts. Such models require reliable natural history inputs to make accurate predictions on health and economic outcomes. Yet, hepatitis C virus disease progression is known to vary widely in the literature and published inputs are currently outdated. The objectives of this study were to obtain updated estimates of fibrosis progression rates (FPR) in treatment-naïve patients with CHC and to explore sources of heterogeneity.

Design

A systematic review was conducted using Ovid-MEDLINE, Ovid-EMBASE and PubMed databases (January 1990 to January 2018) to identify observational studies of hepatic fibrosis in treatment-naïve patients with CHC.

Outcomes

SUBMITTER: Erman A 

PROVIDER: S-EPMC6858137 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature