Evolving rifampicin and isoniazid mono-resistance in a high multidrug-resistant and extensively drug-resistant tuberculosis region: a retrospective data analysis.

ABSTRACT: OBJECTIVES:South Africa ranks among the highest drug-resistant tuberculosis (DR-TB) burdened countries in the world. This study assessed the changes in resistance levels in culture confirmed Mycobacterium tuberculosis (MTB) in the highest burdened province of South Africa during a period where major changes in diagnostic algorithm were implemented. SETTING:This study was conducted at the central academic laboratory of the KwaZulu-Natal province of South Africa. PARTICIPANTS:We analysed data for all MTB cultures performed in the KwaZulu-Natal province between 2011 and 2014. The data were collected from the laboratory information system. RESULTS:Out of 88 559 drug susceptibility results analysed, 18 352 (20.7%) were resistant to rifampicin (RIF) and 19 190 (21.7%) showed resistance to isonia

SUBMITTER: Mvelase NR 

PROVIDER: S-EPMC6858147 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature