Association between genetically determined leptin and blood lipids considering alcohol consumption: a Mendelian randomisation study.

ABSTRACT:

Objectives

The objective of this study was to evaluate the association of genetically determined leptin with lipids.

Design

We conducted a Mendelian randomisation study to assess a potential causal relationship between serum leptin and lipid levels. We also evaluated whether alcohol drinking modified the associations of genetically determined leptin with blood lipids.

Setting and participants

3860 participants of the Framingham Heart Study third generation cohort.

Results

Both genetic risk scores (GRSs), the GRS generated using leptin loci independent of body mass index (BMI) and GRS generated using leptin loci dependent of BMI, were positively associated with log-transformed leptin (log-leptin). The BMI-independent leptin GRS was associated with log-transforme

SUBMITTER: Shen L 

PROVIDER: S-EPMC6858149 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature