A pharmacokinetic-pharmacodynamic assessment of oral antibiotics for pyelonephritis.

ABSTRACT: Antibiotic resistance to oral antibiotics recommended for pyelonephritis is increasing. The objective was to determine if there is a pharmacological basis to consider alternative treatments/novel dosing regimens for the oral treatment of pyelonephritis. A systematic review identified pharmacokinetic models of suitable quality for a selection of antibiotics with activity against Escherichia coli. MIC data was obtained for a population of E. coli isolates derived from patients with pyelonephritis. Pharmacokinetic/pharmacodynamic (PK/PD) simulations determined probability of target attainment (PTA) and cumulative fraction response (CFR) values for sub-populations of the E. coli population at varying doses. There are limited high-quality models available for the agents investigated. Pharmacoki

SUBMITTER: Cattrall JWS 

PROVIDER: S-EPMC6858297 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature