Maximal information transmission is compatible with ultrasensitive biological pathways.

ABSTRACT: Cells are often considered input-output devices that maximize the transmission of information by converting extracellular stimuli (input) via signaling pathways (communication channel) to cell behavior (output). However, in biological systems outputs might feed back into inputs due to cell motility, and the biological channel can change by mutations during evolution. Here, we show that the conventional channel capacity obtained by optimizing the input distribution for a fixed channel may not reflect the global optimum. In a new approach we analytically identify both input distributions and input-output curves that optimally transmit information, given constraints from noise and the dynamic range of the channel. We find a universal optimal input distribution only depending on the input nois

SUBMITTER: Micali G 

PROVIDER: S-EPMC6858467 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature