Lipid synthesis and transport are coupled to regulate membrane lipid dynamics in the endoplasmic reticulum.

ABSTRACT: Structural lipids are mostly synthesized in the endoplasmic reticulum (ER), from which they are actively transported to the membranes of other organelles. Lipids can leave the ER through vesicular trafficking or non-vesicular lipid transfer and, curiously, both processes can be regulated either by the transported lipid cargos themselves or by different secondary lipid species. For most structural lipids, transport out of the ER membrane is a key regulatory component controlling their synthesis. Distribution of the lipids between the two leaflets of the ER bilayer or between the ER and other membranes is also critical for maintaining the unique membrane properties of each cellular organelle. How cells integrate these processes within the ER depends on fine spatial segregation of the molecul

SUBMITTER: Balla T 

PROVIDER: S-EPMC6858525 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature