An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.

ABSTRACT: Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; n_control = 13; n_AD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. It was demonstrated that most circRNA-AD associations are independent of changes in cognate linear messenger RNA expression or estimated brain cell-type proportions. Evidence was provided for circRNA expression changes occurring early in presymptomatic AD and in

SUBMITTER: Dube U 

PROVIDER: S-EPMC6858549 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature