Planar three-coordinate iron sulfide in a synthetic [4Fe-3S] cluster with biomimetic reactivity.

ABSTRACT: Iron-sulfur clusters are emerging as reactive sites for the reduction of small-molecule substrates. However, the four-coordinate iron sites of typical iron-sulfur clusters rarely react with substrates, implicating three-coordinate iron. This idea is untested because fully sulfide-coordinated three-coordinate iron is unprecedented. Here we report a new type of [4Fe-3S] cluster that features an iron centre with three bonds to sulfides, and characterize examples of the cluster in three oxidation levels using crystallography, spectroscopy, and ab initio calculations. Although a high-spin electronic configuration is characteristic of other iron-sulfur clusters, the three-coordinate iron centre in these clusters has a surprising low-spin electronic configuration due to the planar geometry and sh

SUBMITTER: DeRosha DE 

PROVIDER: S-EPMC6858550 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature