Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder.

ABSTRACT: The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

SUBMITTER: Viola TW 

PROVIDER: S-EPMC6858578 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature