Evolution of the new head by gradual acquisition of neural crest regulatory circuits.

ABSTRACT: The neural crest, an embryonic stem-cell population, is a vertebrate innovation that has been proposed to be a key component of the 'new head', which imbued vertebrates with predatory behaviour^1,2. Here, to investigate how the evolution of neural crest cells affected the vertebrate body plan, we examined the molecular circuits that control neural crest development along the anteroposterior axis of a jawless vertebrate, the sea lamprey. Gene expression analysis showed that the cranial subpopulation of the neural crest of the lamprey lacks most components of a transcriptional circuit that is specific to the cranial neural crest in amniotes and confers the ability to form craniofacial cartilage onto non-cranial neural crest subpopulations³. Consistent with this, hierarch

SUBMITTER: Martik ML 

PROVIDER: S-EPMC6858584 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature